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Peptides having nitric oxide production inhibitory activity

机译：具有一氧化氮产生抑制活性的肽

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摘要

The present invention relates to a compound of the formula (I) wherein R1 is benzofuranyl substituted by halogen, or styryl substituted by halogen; R2 is substituted hydroxy, substituted mercapto or substituted sulfonyl; and X is or pharmaceutically acceptable salts thereof. The compound (1) of the present invention and pharmaceutically acceptable salts thereof possess a strong inhibitory activity on the production of nitric oxide (NO), and are useful for prevention and/or treatment of NO-mediated diseases in human being and animals

机译：本发明涉及式（I）化合物，其中R1是被卤素取代的苯并呋喃基或被卤素取代的苯乙烯基; R2是取代的羟基，取代的巯基或取代的磺酰基; X是或其药学上可接受的盐。本发明的化合物（1）及其药学上可接受的盐对一氧化氮（NO）的产生具有强的抑制活性，并且可用于预防和/或治疗人和动物中的NO介导的疾病。

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公开/公告号JP2004517877A

专利类型
公开/公告日2004-06-17

原文格式PDF
申请/专利权人藤沢薬品工業株式会社;
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申请/专利号JP20020556609
发明设计人嶋一郎;大川武彦;佐藤健太郎;石橋直樹;今村健一郎;
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申请日2001-12-18
分类号C07K5/078;A61K31/436;A61K38/00;A61P1/04;A61P1/16;A61P1/18;A61P3/10;A61P9/00;A61P9/04;A61P9/10;A61P9/14;A61P11/00;A61P11/06;A61P13/12;A61P15/00;A61P15/10;A61P17/00;A61P17/04;A61P19/02;A61P19/06;A61P19/10;A61P21/04;A61P25/00;A61P25/02;A61P25/04;A61P25/06;A61P25/16;A61P25/28;A61P27/02;A61P27/06;A61P27/10;A61P27/12;A61P27/14;A61P29/00;A61P31/04;A61P31/12;A61P31/22;A61P35/00;A61P35/04;A61P37/02;A61P37/06;A61P37/08;A61P43/00;
国家 JP
入库时间 2022-08-21 23:26:24

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