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Enzymatic hydrolysis production method of C-10 or C-13 hydroxyl-containing taxane, enzymatic esterification production method of C-10 acyloxy-containing taxane, and production of C-13 acyloxy-containing taxane
Enzymatic hydrolysis production method of C-10 or C-13 hydroxyl-containing taxane, enzymatic esterification production method of C-10 acyloxy-containing taxane, and production of C-13 acyloxy-containing taxane
An enzymatic hydrolysis method, wherein one or more C-10 acyloxy-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups. Also provided is an enzymatic esterification method, wherein one or more C-10 hydroxyl-bearing taxanes are contacted with an acylating agent and an enzyme or microorganism capable of esterifying said hydroxyl groups to form acyloxy groups. Further provided is an enzymatic hydrolysis method, wherein one or more C-13 acyloxy-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups. The methods are especially useful for the preparation of compounds which may be employed as intermediates in the preparation of taxanes such as taxol.
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