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Vector, which is complexed with it and bifunctional molecules for targeting gene delivery
Vector, which is complexed with it and bifunctional molecules for targeting gene delivery
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机译:与载体和双功能分子复合的载体,用于靶向基因递送
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摘要
Methods and products for targeting delivery vectors, such as adenoviral gene delivery particles, to selected cell types are provided. The methods rely on targeting by a bifunctional molecule that specifically complexes with a protein on the vector particle surface and with targeted cell surface proteins. The targeted cell surface proteins are any that activate the phosphatidylinositol-3-OH kinases. The bifunctional molecules, compositions, kits, and methods of preparation and use of the vector/bifunctional molecules for gene therapy are provided.
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