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Compound of hepatitis B virus antigen polypeptide and heat shock protein and its application
Compound of hepatitis B virus antigen polypeptide and heat shock protein and its application
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机译:乙肝病毒抗原多肽与热休克蛋白的复合物及其应用
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摘要
The present invention provides a kind of HBV-antigen bound to heat shock proteins(hsps) which comprises core antigen, surface antigen and polymerase antigen. The present invention also provides a complex of HBV antigen bound to heat shock protein gp96 and hsp78, as well as a method for preparing the complex. The complex includes a complex of gp96 and hsp78 non-covalently bound to antigenic polypeptide, as well as a fusion protein of both which results from covalent binding. Such complex can be used to prepare therapeutic vaccine for treating hepatitis B and primary hepatocellular carcinoma.
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