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Antibacterial therapy with bacteriophage genotypically modified to delay inactiovation by the host defense system
Antibacterial therapy with bacteriophage genotypically modified to delay inactiovation by the host defense system
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机译:基因改造的噬菌体的抗菌疗法可延缓宿主防御系统的失活
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摘要
The present invention is directed to bacteriophage therapy, using methods that enable the bacteriophage to delay inactivation by any and all parts of the host defense system (HDS) against foreign objects that would tend to reduce the numbers of bacteriophage and/or the efficiency of those phage at killing the host bacteria in an infection. Disclosed is a method of producing bacteriophage modified for anti-HDS purposes, one method being selection by serial passaging, and the other method being genetic engineering of a bacteriophage, so that the modified bacteriophage will remain active in the body for longer periods of time than the wild-type phage.
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