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Method fo assessing antidepressant drug therapy via transport inhibition of monoamine neurotransmitters
Method fo assessing antidepressant drug therapy via transport inhibition of monoamine neurotransmitters
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机译:通过单胺类神经递质的转运抑制评估抗抑郁药物治疗的方法
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摘要
A method of measuring the individual response to antidepressant drug therapy on the transport inhibition of monoamine neurotransmitters involves in vitro monitoring of radiolabeled monoamine neurotransmitter transport into cells transfected with transport proteins similar to those on neural cells of the individual being studied. The transport occurs in unbuffered serum of the individual who is undergoing or will later undergo pharmaceutical treatment for depression or other neuropsychiatric disorders. The use of buffers is avoided so that the sensitive balance of bound/free drug within the individuals serum is not disrupted prior to or during testing.
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