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Method of and detecting apparatus and detecting chip for single base substitution SNP and point mutation of genes

机译：单碱基取代单核苷酸多态性和基因点突变的方法，检测装置和检测芯片

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摘要

Space part S within a detecting chip 2 for single base substitution SNP and point mutation of genes where a plurality of gold electrodes 8 are formed in the base 7 of closed space part S, oligonucleotides 10 with different gene sequences are fixed to the gold electrodes 8, a common electrode 16 arranged not to contact the gold electrodes 8, are filled with DNA samples, voltage is applied between the common electrode 16 and the gold electrode 8, and current is measured to allow the double-stranded DNA to be detected and analyzed. It becomes possible to detect and analyze a large number of single base substitution SNP and point mutation for a plurality of DNA samples.

机译：检测芯片 2 中的空间部分S，用于单碱基替换SNP和基因的点突变，在碱基 7 8 。 B>封闭空间部分S中，具有不同基因序列的寡核苷酸 10 固定在金电极 8 上，公共电极 16 排列成不接触金电极 8 ，充满DNA样品，在公共电极 16 和金电极 8 之间施加电压，电流为进行测量以检测和分析双链DNA。可以检测和分析大量DNA样品的大量单碱基取代SNP和点突变。 展开▼

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公开/公告号US2004185462A1

专利类型

公开/公告日2004-09-23

原文格式PDF

申请/专利权人 TUM GENE INC.;
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申请/专利号US20030624567

发明设计人 KAZUHIKO UCHIDA;TAKATOSHI MIYAHARA;SHIGEORI TAKENAKA;
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申请日2003-07-23

分类号C12Q1/68;C12M1/34;

国家 US

入库时间 2022-08-21 23:21:55

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1. 基因的一个碱基置换SNP与点突变的检测方法、检测装置及其检测芯片 [P] . 中国专利： CN100402661C . 2008.07.16

2. 基因的一个碱基转换SNP与点突变的检测方法、检测装置及其检测芯片 [P] . 中国专利： CN1320212A . 2001-10-31

3. METHOD AND DEVICE FOR DETECTING ONE BASE SUBSTITUTION SNP AND POINT MUTATION OF GENE AND DETECTION CHIP [P] . 日本专利： JP2001050931A . 2001-02-23

机译：检测一碱基取代单核苷酸多态性和基因点突变及检测芯片的方法和装置

4. METHOD FOR DETECTING SINGLE NUCLEOTIDE POLYMORPHISM (SNP) AND POINT MUTATION IN GENE, DETECTION APPARATUS AND DETECTION CHIP [P] . 欧洲知识产权局专利： EP1120646A4 . 2006-09-06

机译：检测单核苷酸多态性和基因突变的方法，检测装置和检测芯片

5. METHOD FOR DETECTING SINGLE NUCLEOTIDE POLYMORPHISM (SNP) AND POINT MUTATION IN GENE, DETECTION APPARATUS AND DETECTION CHIP [P] . 世界知识产权组织专利： WO0111351A1 . 2001-02-15

机译：检测单核苷酸多态性（SNP）和基因突变的方法，检测装置和检测芯片

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