Use of Vitamin D-Derivatives in the Treatment of Osteoporosis and related bone disorders, as well as novel vitamin D3-Deviratives

摘要

Compounds of the formula (I) wherein X represents hydrogen or hydroxy; Y represents oxygen or sulphur or oxidized sulphur selected from the groups S(O) and S(O₂); R¹ and R², which may be the same or different, represent hydrogen or a residue after removal of 1 hydrogen atom from a straight, branched or cyclic, saturated or unsaturated, C₁-C₆-hydrocarbon; or R¹ and R2, together with the carbon atom to which they are attached (marked with an asterisk in formula (I)), bearing the group X, form a C₃-C₈ carbocyclic ring; Q represents a diradical residue after removal of 2 hydrogen atoms from a straight, branched or cyclic, saturated or unsaturated C₁-C₈-hydrocarbon; R³ represents hydrogen or a residue after removal of 1 hydrogen atom from a straight, branched or cyclic, saturated or unsaturated C₁-C₆-hydrocarbon; R¹, R² and/or Q is optionally substituted with one or more deuterium or fluorine atoms; and n is 0 or 1; and derivatives of the compounds of formula (I) in which one or more hydroxy groups have been transformed into O-acyl or O-glycosyl groups, or a phosphate ester, such masked groups being hydrolyzable in vivo; may be used for the preparation of a medicament for the treatment and/or prophylaxis of osteoporosis and related bone disorders. chemistry chemdraw filechemistry mol file