Process for isolation of hepatoprotective agent 'oleanolic acid' from Lantana camara

摘要

Accordingly the present invention provides an improved and economical process for the isolation of oleanolic acid from the roots of Lantana camara, which comprises of drying, grinding and defattening of Lantana camara roots with light petroleum followed by over night extractions at room temperature (30-40° C.) three times with a single solvent selected from CH₂Cl₂, CHCl₃, EtOAc, ether, acetone, MeOH, EtOH etc., removal of solvent under vacuum at 35-45° C., precipitation of crude extract and repeated partial crystallization of precipitate with a single solvent selected from CH₂Cl₂, CHCl₃, EtOAc, ether, acetone, MeOH, EtOH, H₂O and others resulting in the isolation of oleanolic acid with 1% yield.