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Method and compositions using anthrax immune globulin to provide passive immunity against lethal infections from bacillus anthracis
Method and compositions using anthrax immune globulin to provide passive immunity against lethal infections from bacillus anthracis
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机译:使用炭疽免疫球蛋白提供被动免疫以抵抗炭疽杆菌致死性感染的方法和组合物
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摘要
Methods and compositions capable of quickly transferring antibody-mediated protection against lethal infections of B. anthracis in an animal without benefit of vaccination against B. anthracis. The present invention method includes providing plasma from donors, said plasma having a measurable level of immunologically active immunoglobulin against anthrax; and administering a predetermined quantity of said plasma product to the animal, wherein an antibody-mediated protection against lethal infections of B. anthracis is elicited. Methods of manufacturing a composition to transfer passive anthrax immunity to an animal include providing plasma from hyper-immunized donors, having a measurable level of immunologically active immunoglobulin against anthrax; and purifying said plasma that substantially preserves the titer of the immunoglobulin in the plasma. The plasma may be screened for infectious diseases and for toxin neutralization antibodies (TNA). The invention may also include the steps of pooling the plasma from donors and inactivating residual viral activity.
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