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Design and planning system for improving the survival rate of injected structures

机译:提高注射结构成活率的设计规划系统

摘要

The present invention includes a method for evaluating the acceptability of a device for the delivery of cells in a cell implantation therapy comprising:;determining a first rate of cell survival in a stable environment,;evaluating a second rate of survival during a procedure using a device that manipulates cells, and;comparing the first and second rates of survival to determine the effect of the device used during the procedure on cell survival rates to establish a base line effect of the manipulative procedure on cell survivability. That method may be practiced wherein after determining the second survival rate, modifying the design of the device, evaluating a third rate of survival after modifying the design of the device to determine if the change has increased the rate of survival during the procedure. The method is particularly effective where the procedure is selected from the group consisting of cell harvesting, cell transport, cell implantation, and cell delivery. The procedure may include, for example, a peristalsis process for movement of cells during the procedure or a bolus flow of cells for movement of cells during the procedure.
机译:本发明包括一种用于评估在细胞植入疗法中用于递送细胞的装置的可接受性的方法,该方法包括:确定在稳定环境中的第一细胞存活率;使用该方法评估在手术过程中的第二存活率。操纵细胞的装置,以及;比较第一和第二存活率,以确定在该过程中使用的装置对细胞存活率的影响,以建立操纵过程对细胞存活率的基线影响。可以实践该方法,其中在确定第二生存率之后,修改设备的设计,在修改设备的设计之后评估第三生存率,以确定该变化是否增加了该过程中的生存率。当该程序选自细胞收获,细胞转运,细胞植入和细胞递送时,该方法特别有效。该过程可以包括例如用于在过程中使细胞运动的蠕动过程或用于在过程中使细胞运动的细胞团流。

著录项

  • 公开/公告号US6749833B2

    专利类型

  • 公开/公告日2004-06-15

    原文格式PDF

  • 申请/专利权人 BRESAGEN LIMITED;

    申请/专利号US20010866524

  • 发明设计人 TIMOTHY POSTON;RAGHU RAGHAVAN;

    申请日2001-05-25

  • 分类号A61K490/00;

  • 国家 US

  • 入库时间 2022-08-21 23:18:47

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