Heterocycle substituted purine derivatives as potent antiproliferative agents

摘要

The compounds of the present invention are 2,6,9-trisubstituted purine derivatives which are inhibitors of cyclin/cdk complexes. The compounds of the current invention also are potent inhibitors of human cellular proliferation. As such, the compounds of the present invention constitute pharmaceutical compositions with a pharmaceutically acceptable carrier. Such compounds are useful in treating a disorder mediated by elevated levels of cell proliferation in a mammal compared to a healthy mammal by administering to such mammal an effective amount of the compound. Examples of the compounds of the present invention are represented by the following chemical structures: ;wherein:;V;NH;;O;;S; or;CH₂;;R₇ is a heterocycle selected from the group consisting of:;thiophene;;furan;;pyrrole;;thiazole;;pyrazole;;imidazole;;isoxazole;;isothiazole; and;1,3,4-thiadiazole;;and Y, A, R₁, R₂, R₃, R₄, and n₁ are defined herein.