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Biaryl substituted purine derivatives as potent antiproliferative agents
Biaryl substituted purine derivatives as potent antiproliferative agents
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机译:联芳基取代嘌呤衍生物作为有效的抗增殖剂
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摘要
The compounds of the present invention are 2,6,9-trisubstituted purine derivatives which are inhibitors of cyclin/cdk complexes. The compounds of the current invention also are potent inhibitors of human cellular proliferation. As such, the compounds of the present invention constitute pharmaceutical compositions with a pharmaceutically acceptable carrier. Such compounds are useful in treating a disorder mediated by elevated levels of cell proliferation in a mammal compared to a healthy mammal by administering to such mammal an effective amount of the compound. Examples of the compounds of the present invention are represented by the following chemical structures: wherein:X=N;V=NH; O;S; orCH2;A=CH2; (CH2)2;(CH2)3;OCH2CH2; orCHCH3;and Y, R1, R2, R3, R4, and n1 are defined herein.展开▼