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Compositions and methods for enhanced biostability and altered biodistribution of oligonucleotides in mammals
Compositions and methods for enhanced biostability and altered biodistribution of oligonucleotides in mammals
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机译:用于增强哺乳动物中寡核苷酸的生物稳定性和改变的生物分布的组合物和方法
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摘要
The invention is directed to oligonucleotides and oligonucleosides functionalized to include lipophilic moieties and having improved biostability and altered biodistribution in mammals. In one embodiment, such lipophilic oligonucleotide conjugates are used in a method of targeting antisense oligonucleotides to hepatic tissues and thereby preferentially modulating gene expression in the liver and associated tissues of a mammal.
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