Human and rat pgc-3, ppar-gamma coactivations and splice variants thereof

摘要

A gene PGC-3 PPAR gamma coactivator-3, and it's role in regulating the transcriptional activity of peroxisome proliferator activated receptor-Y PPAR-Y in adipose tissue. PGC-3 is highly expressed in human white adipose tissue and has utility in the development of new therapeutic agents for use in the treatement of obesity and other related disorders such as non-insulin dependent diabetes mellitus, insulin resistance syndrome, dyslipidemia, and atherosclerosis.