Process for producing organotitanium compound and process for addition reaction

摘要

A process for producing an organotitanium compound capable of regioselectively converting a substituted acetylene compound into polysubstituted benzene or polysubstituted pyridine. The process comprises reacting an acetylene compound represented by the formula (1) ;[where R¹ and R² denote a C_1-20 alkyl group or the like] in the presence of a prescribed titanium compound and a Grignard reagent with a compound represented by the formula (4) ;[where R³ and R⁴ denote a hydrogen atom or the like] and further reacting with a compound represented by the formula (5) ;[where R⁵ denotes a hydrogen atom or the like, Z denotes CR′ (where R′ denotes a hydrogen atom or the like), nitrogen atom, X⁶ denotes a halogen atom or the like, and m is 0 or 1];thereby giving the titanium compound represented by the formula (6) and/or (7). ;[where R¹˜R⁵, Z, X⁶, and m are defined as above; and X^p and X^q denote any of X¹˜X⁴].