Advancing the detection of hearing loss in newborns through parallel genetic analysis

摘要

A newborn screening method is provided for detecting the causes of hereditary hearing loss. Patient specimen amplicons are synthesized, wherein the amplicon is an oligonucleotide specific to a gene selected from the group consisting of cytomegalovirus (CMV), mitochondria, and connexin 26 (Cx26). They are then spotted on a substrate and immobilized as a target for microarray production as wild type and mutated alleles are allowed to hybridize thereto and undergo image analysis.