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Genetic vaccines for the production of chicken egg-yolk antibodies against enterotoxigenic escherichia coli and other pathogens

机译：用于生产抗肠毒素性大肠杆菌和其他病原体的鸡卵黄抗体的基因疫苗

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摘要

Genetic vaccine which comprises plasmid(s) containing genes coding for antigens of enterotoxigenic Escherichia coli (ETEC) strains is disclosed. Additionally, plasmids may consist of multiple copies of the same antigen (i.e. K88 or K99 fimbrial antigen) or multiple antigens (ie. K88 and K99 fimbrial antigens) and genetic adjuvants such as cytokines (IL-2, IL-4 GM-CSF), costimulatory molecules (CD80 CD86) or chemokines or immunostimulatory sequences. A method for isolating antibodies from chicken egg yolk for passive immunization of animals, as well as humans to control diarrhoeal diseases using the genetic vaccines is also disclosed.

机译：公开了一种遗传疫苗，该遗传疫苗包含一种质粒，该质粒含有编码产肠毒素的埃希氏大肠杆菌（ETEC）菌株抗原的基因。另外，质粒可以由相同抗原（即K88或K99纤维抗原）的多个拷贝或多个抗原（即K88和K99纤维抗原）和遗传佐剂（例如细胞因子）组成（IL-2，IL-4 GM-CSF），共刺激分子（CD80 CD86）或趋化因子或免疫刺激序列。还公开了一种使用遗传疫苗从鸡卵黄中分离抗体以进行动物以及人的被动免疫以控制腹泻疾病的方法。

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公开/公告号US2004087522A1

专利类型
公开/公告日2004-05-06

原文格式PDF
申请/专利权人 MARQUARDT RONALD;CHO SUK-HYEON;LOEWEN PETER;MADHYASTHA SRINIVASA;
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申请/专利号US20030169027
发明设计人 RONALD MARQUARDT;SUK-HYEON CHO;PETER LOEWEN;SRINIVASA MADHYASTHA;
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申请日2003-05-27
分类号A61K48/00;A61K39/395;
国家 US
入库时间 2022-08-21 23:15:13

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