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Circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3 and prostate cancer risk
Circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3 and prostate cancer risk
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机译:循环胰岛素样生长因子-I,胰岛素样生长因子结合蛋白-3和前列腺癌的风险
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摘要
Methods of predicting a propensity to developing prostate cancer are presented. The method consists of measuring the IGF status of individual. Individuals with high IGF status, as compared with normal reference range values, are at increased risk for developing prostate cancer. More particularly, the IGF status may be determined by measuring IGF-I levels and/or IGFBP-3 levels. High IGF and low IGFBP levels are indicative of a high IGF status. A method of determining the prognosis of existing prostate cancers or of monitoring disease progression involves determining the IGF/PSA status of an individual. Individuals with a high IGF/PSA status (both high IGF status and high PSA levels) tend to develop severe prostate cancer and have a poorer overall prognosis.
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