;from a compound having the formula: ;wherein R1 is hydrogen, fluorine, chlorine or SiR5R6R7, wherein R5, R6, and R7 are independently the same or different an alkyl group or an aryl group, R2 is an alkyl group, R3 is a protecting group, R4 is an alkyl group, an allyl group, a propargyl group —CO2H, or a benzyl group, R8 is —CO2R10, wherein R10 is an alkyl group or an aryl group, X1 is OH and X2 is H, includes the step of exposing compound (III) to at least one of an organic acid or an inorganic acid. A compound has the general formula (III)."/>
Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins
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Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins
Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins
A method of synthesizing a compound having the formula: ;from a compound having the formula: ;wherein R1 is hydrogen, fluorine, chlorine or SiR5R6R7, wherein R5, R6, and R7 are independently the same or different an alkyl group or an aryl group, R2 is an alkyl group, R3 is a protecting group, R4 is an alkyl group, an allyl group, a propargyl group —CO2H, or a benzyl group, R8 is —CO2R10, wherein R10 is an alkyl group or an aryl group, X1 is OH and X2 is H, includes the step of exposing compound (III) to at least one of an organic acid or an inorganic acid. A compound has the general formula (III).
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机译：一种合成具有以下化学式的化合物的方法： -C00001“ imgContent =” undefined“ imgFormat =” GIF“ wi =” 144.9819“ /> < ExternalFileRef externalType =“ chemistry mol file” file =“ US06723853-20040420-C00001.MOL” id =“ CHEMMOL-00001” /> ;来自具有以下化学式的化合物： <图像alt =”嵌入式图像“ file =” US06723853-20040420-C00002.GIF“ he =” 85.70205“ id =” EMI-C00002“ imgContent =” undefined“ imgFormat =” GIF“ wi =” 152.4096“ /> ;其中R 1 是氢，氟，氯或SiR 5 R 6 R 7 ，其中R 5 ，R 6 和R 7 独立相同或不同的烷基或芳基，R 2 是烷基，R 3 是保护基，R 4 是烷基，烯丙基，炔丙基＆mdash; CO 2 H或苄基，R 8 是＆mdash; CO 2 R 10 ，其中R 10 是烷基或芳基，X 1 是OH，X 2 H是H，包括将化合物（III）暴露于有机酸或无机酸中的至少一种的步骤。化合物具有通式（III）。
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