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Immunotoxins, comprising an internalizing antibody, directed against malignant and normal cells
Immunotoxins, comprising an internalizing antibody, directed against malignant and normal cells
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机译:包含内化抗体的免疫毒素,针对恶性和正常细胞
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摘要
The present invention relates to immunotoxins that effectively kill malignant cells having a given marker. The immunotoxins are reagents that comprise internalizing antibodies conjugated to cytotoxic ribonucleases or fragments thereof. The internalizing antibodies are capable of binding with a chosen tumor cell, and thereby confer little non-specific toxicity to the immunotoxin in a host. The immunotoxins exhibit up to 2000-fold higher toxicity against malignant B cells than did the ribonuclease counterparts alone.
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