Arilmetilaminas replaced, Pharmaceutical compositions and Use thereof for the manufacture of a medicament

摘要

The alternative arilmethamine includes a formula compound (1),wherein Ar is an aryl group or a heteroaryl group, and the group of formula (2) is beta with respect to the group of formula (3),In arilo: the dividing line is a simple or double-sided link; R1 and R2 are independent hydrogen or low tar; R3 is arilo, arilalquenilo, cyclo cycloquilo, cycloquilo, heteromorphous, heteromorphous, heteromorphous alquenilo, heterocyclopropene, An isocyclic compound associated with carbon or alternative tar consisting of one or more hydroxyl, alcoxi, acrylonitrile, cyclopropyl, isocyclic, R6, - or6, - S (o) mr6 O-C (= O) - R6; R4 is hydrogen, acid, alcox, hydrocarbon, carbon, cyanogen, halogen, hydrogen, -C (= O) - ny1y2, or alternative asphalt such as Alcoy, lcarbonilamine, polyfonilamino, hydroxi, - S (o) m-codilo-ny1y2;R5 is hydrogen, acyl, alkoxy, alkyloxycarbonyl, aryl, carboxy, cyano, halo, heteroaryl, heteroaryloxy, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylalkyl, heteroarylalkyloxy, hydroxy, trifluoromethyl, -C (= O) -NY1Y2, -NZ1-C, -6alkylene-R7 or alkyl optionally substituted with alkoxy, alkylcarbonylamino, alkylsulfonylamino, aryl, heteroaryl, heterocycloalkyl, hydroxy, ureido, -C (= O) -NY1Y2, -SO2-NY1Y2, -S (O) m-alkyl or -NY1Y2 ; R6 is aryl or heteroaryl; R7 is hydroxy, alkoxy, ureido, -C (= O) -NY1Y2, -SO2-NY1Y2, -S (O) m-alkyl or -NY1Y2; R8 is hydrogen or lower alkyl; Y1 and Y2 are independently hydrogen, alkenyl, alkyl, aryl, arylalkyl,Cyclopropyl, heteromorphic, heteromorphic, heteromorphic or heteromorphic cyclopropyl or class ii-ny1y2 can form a periodic ammonia water; Z1 is O (o) m or nr8; m is zero or 1-2 integer; n is zero or 1-4 integer; n-oxidizes this compound, the product of this compound, the drug acceptable salt of this compound, a solution This compound and the hydrate of this compound have triploid inhibitory activity, including the pharmaceutical components of these compounds, and the use of these compounds to make drugs to treat patients with conditions and diseases,Or a disorder that can be improved by using triple velocity inhibitors, such as asthma and inflammation, to name just a few.