Derivatives of 2 - phenoxy - 1 - (4 - bencilpiperazin - 1 - il) ethan-1-one, monohydrochloride dihydrochloride and their salts, a process for their preparation, and method of Use thereof for the production of a Radio Pharmaceutical Product for the diagnosis of Alzheimer's disease in a

摘要

From 2-phenyl-1 - (4-benzo-p-1-il) - ethane-1-ona, preparation (1),Where X1 and X2 are independent,Halo, R1 and R2 are independent,Hydrogen or asphalt, R3 is hydrogen, amine, single rent ore, karaylamine, single aralquilamine, tar amide, alquenilcarbonilamine, halocarbon tar amide, arilcarbonilamina, alcoxyl lcarbonilamine, alcoxicarbonilla quilcarbonilamina, glizine, glycine, single crystal tar, diene propylene diamide, carboxamide, aminoacrylonitrile ammonia, (ammonium carbamate) (TAR) - glyceramide (ALCOXY lcarbonil) glyceramide, urea, single tar, single aliyidu, single alakilluyidu or methylamine; select any X1 or x2 from groups 123I, 125I, 128I, 131I, 75br, 80br and 18F; or the carbon atom in compound 11C;Or a salt for medicine. It also describes the derivatives of 2-phenyl-1 - (4-phenyl-1-il) - ethane-1-ona, wherein R3 is a radical n (R4) R5, R4 is hydrogen, R5 is a condensate which can be combined with a radioactive metal atom, and the condensate is composed of 99mTc, 186re and 188Re. 1. Radio equation compound (1) has the ability to penetrate the blood barrier in the brain and bind to CCR1 receptors in brain tissue with Alzheimer's disease. Therefore,They are used to make radio drugs for diagnosing Alzheimer's in a person.