Therapeutic agent for hepatitis C that includes a Condensed Ring Compound, Condensed Ring Compound, Pharmaceutical composition containing Same, thiazole and benzimidazole biphenyl Compounds, useful as Intermediates for producing Said Compounds, the use of compound Ring

摘要

Therapeutic agent for hepatitis C comprising a fused ring compound of the formula [1] where a dotted line is a single bond or a double bond; G1 is C (-R1) or a nitrogen atom; G2 is C (-R2) or a nitrogen atom; G3 is C (-R3) or a nitrogen atom; G4 is C (-R4) or a nitrogen atom; G5, G6, G8 and G9 are each independently a carbon atom or a nitrogen atom; G7 is C (-R7),An oxygen atom, a sulfur atom, or an optional nitrogen atom, is replaced by R8; wherein R1, R2, R3 and R4 are each hydrogen atoms, regardless of their (1) alkane C1-6, (3) hydrogen carbide, (4) cyanogen, (5) nitro, (6) C1-6 tar, they can be replaced by 1 to 3 substitutes in the next group. A. [group: halogen atom, one hydroxyl group, carboxilo, amino, alcoxi C1-6, alcoxi c1-6alcoxi C1-6, alcoxin C1-6 and rental C1-6],(7) - cora1, where ra1 is a C1-6 tar, optionally replaceable (as defined above) or aril C6-14 tar, optionally replaceable with 1 to 5 selected substitutes from group B, [group B: halogen, cyanogen, nitrogen, C1-6 tar, C1-6 halogenated tar, C1-6 alkane, C1-6, - (CH2) r-corb1, -(N2R and N2R are independent, A hydrogen atomC1-6 or alternative C1-6 tar (as described above),(9) - C (= nra4) NH2, where RA4 is a hydrogen atom or oxyhydrogen compound, (10) - nhr5, where ra5 is a hydrogen atom, C1-6 alkane or C1-6 alkylsulfonate (11) - RA6, where RA6 is a hydrogen atom or alternative C1-6 tar (as described above),(12) - so2ra7, where ra7 is a hydroxy, amino, C1-6 tar or hired C1-6, or (13) - P (= O) (ora31) 2, where ra31 is a hydrogen atom, C1-6 tar (as described above) or aril C6-14 tar (C1-6) is an optional alternative, replaced by 1 to 5 alternatives selected in the previous group B, Y (14) one to four heteromorphic atoms selected from the oxygen atom, one nitrogen atom and one sulfur atom; R7 and R8 are an alternative C1-6 hydrogen atom or tar, respectively (as described above);Propyl O (3) the remaining formulas [2], [3], [4] or [5], where u and V are independent,Integers 1 to 3; ring a is (1) arilo C6-14, (2) cycloquilo C3-8, (3) cycloquenio C3-8, or (4) a heteromorphic group consisting of 1 to 4 heteromorphic atoms selected from oxygen, nitrogen, and sulfur atoms; R5 and R6 are (1) a hydrogen atom, (2) a halogen atom, and (3) C1-6 tar, respectively. Options (as mentioned above),O (4) - or8, wherein ra8 is a hydrogen atom, C1-6 tar or aril C6-14 tar C1-6; X is (1) hydrogen atom, (2) halogen atom, (3) cyanogen, (4) nitrogen, (5) amine, alkane C1-6, (6) C1-6 tar, C1-6 alternative (as described above),(8) Alquenilo c2-6 can optionally replace the original a (9) - cora9 with a 1-3 substitute, wherein ra9 is a hydrogen atom or C1-6 (10) - CONH - (CH2) l-ra10, and RA10 is an optional substitute for C1-6 (as described above),C1-6 or C1-6 alkanes and L are 0 or integers 1 to 6, (11) - ora11, where Ra11 is a hydrogen atom or alternative C1-6 hydrocarbon (as defined above).O (12) a formula compound in which the B ring is (1 ') arilo C6-14, (2') C3-8 cyclo, or (3 ') as described above, a heterocyclic group;Each Z is a D group (1 ') selected from the next D group (2'), arilo C6-14 is optionally replaced by 1 to 5, C3-8 cyclopropyl compound selected from the next D group (3 '), and optionally by 1 to 5 to replace the alternative selected from the next D group, 1.2.2 (4 ') aril c6-14c6-14oquile C1-6 is optionally replaced by 1-5 selected substitutes in group D below, or (5') by 1-5 selected substitutes in group D below. In group D, there are 1-4 non atoms selected from oxygen and nitrogen atoms in the heterocycle group. And sulphur.6. [(6 ') C1-6 selects an aperiodic tar to replace with 1-5 of the following alternatives selected in group D, in which case, C1-6 selects an aperiodic tar to replace with C1-6, a set of alternative alternatives to replace with 1-5 alternatives selected in group D; [as mentioned above, group D: (a) an atom Hydrogen, (b) halogen atom, (c) cyanogen, (d) nitrogen, (E) C1-6 tar alternative (as described above),(f) - (CH2) t-cor18 (from now on, each T represents an independent, 0 or 1 to 6 integer)Ra18 is an (1 ') C1-6 alternative (as described above),(2 ') arilo C6-14 is selectively replaced by 1-5, replacing the non periodic group selected in the previous group B or (3'), replacing the non periodic group selected in the previous group B, with 1-4 non normal atoms selected from oxygen, nitrogen and sulfur atoms, (g) - (CH2) t-coor19, wherein ra19 is a hydrogen atom, C1-6 tar can be replaced optionally (as defined above), or aril c6-14c1-6 can be replaced optionally by 1-5 instead of the original B (H) - (CH2) t-conra27ra28, wherein RA27 and RA28 are independent,(1 ') a hydrogen atom (2') C1-6 tar alternative (as described above),3 '(3') arilo C6-14 is selectively changed to 1-5, replacing (4 ') aril c6-14c6-14c6-14c6 selected in the original group B, optionally changing to 1-5, replacing (s) selected in the original group B, (5') an alternative non periodic group, changing to (s) selected in the previous group B, (6 '. " The alternative C1-6 aperiodic heterocyclic tar cycle is replaced by one to five selected substitutes from the former group B, wherein the C1-6 aperiodic hybrid tar cycle is C1-6 tar, replaced by one optional aperiodic group, replacing one to five selected substitutes from the former group B,1. As defined above, (7 ') cycloquilo C3-8 can be optionally replaced by 1 to 5, and (8') cycloquil c3-8c1-6 or (8 ') cycloquil c3-8c1-6 selected from the previous group B can be optionally replaced by 1 to 5, replacing (9') hydroxy or (10 '' alcox C1-6 selected from the previous group B, (i) - (CH2) T-C (= nra33) NH2, wherein RA33 is a hydrogen atom or C1-6 hydrocarbon group, a group of hydroxyl groups or alcoxi C1-6, (J) - (CH2) t-or20, wherein RA20 is (1) (` 1 ') a hydrogen atom, (2'), C1-6 optional alternative tar (as defined above),(3 "alquenilo c2-6 alternative, as described above),1. (4 ') to replace (5') arilo C6-14 selected in the original group A with 1 to 3, to replace (6 ') aril C6-14 selected in the original group B with 1 to 5, to replace (7') selected in the original group B. 1-5 is used to replace 1-6 aperiodic C1-6 asphalt selected in group B, 1-5 (9 ') cyclo-8 alternative selected in group B, and 1-5 (s) selected in group B,O (10 ') cycloquil c3-8c1-6 was voluntarily replaced with the selected substitute in the group B (k) - (CH2) t-o (CH2) p-cora21 before 1-5, wherein ra21 was ammonia water and C1-6 or optional non periodic group was rented instead of 1-5 substitute selected in group B, P was 0 or 1-6 integer, (l) - (CH2) t-nra2ra23, wherein ra22 and ra23 are independent hydrogen atoms respectively, (1 ') (2') C1-6 optional replacement tar (as defined above),(3 ') arilo C6-14 is replaced by alternatives 1 to 5, replacing the 1 to 5 selected in the original group B, (4') aril c6-14c6-14 tar, alternative 1 to 5 selected in the former group B, or (5 ') C1-6 aperiodic alternative to the 1 to 5 selected in the former group B, (6 ') the alternative aperiodic group is replaced by 1 to 5, replacing some C1-6 or C1-6 alkane atoms selected in the previous group B (m) - (CH2) t-ra29co-ra24, ra24 is hydrogen atom, C1-6 or C1-6 alkane atom, ra24 is ammonia water (1'), (2 ') lease C1-6, C1-6, 3',(4 ') arilo C6-14 is selectively changed to 1-5, replacing the (5') non periodic alternative selected in the previous group B, replacing the (s) or (6 ') non periodic condensate reservoir selected in the previous group B with 1-5.