Modified release Pharmaceutical composition suitable for antiarrhythmic Compounds, Process for their preparation, and use of this composition for the manufacture of a Medicament for use in the prophylaxis or treatment of arrhythmia

摘要

Modified release pharmaceutical composition comprising 4 - ({3- [7- (3,3-dimethyl-2-oxobutyl) -9-oxa-3,7-diazabicyclo- [3.3.1] non-3-yl] propyl } amino) benzonitrile, 2- {7- [3- (4-cyano-anilino) propyl] -9-oxa-3,7-diazabicyclo [3.3.1] non-3-yl} tert-butyl ethylcarbamate, 2 - {7- [4- (4-cyanophenyl) butyl] -9-oxa-3,7-diazabicyclo [3.3.1] non-3-yl} ethylcarbamate tert-butyl or 2- {7 - [(2S) -3- (4-cyanophenoxy) -2-hydroxypropyl] -9-oxa-3,7-diazabicyclo [3.3-1 [} tert-butyl ethylcarbamate or a pharmaceutically acceptable salt of any of these compounds,In particular, the modified polymer jelly matrix releases components. In addition, the preparation procedure of the drug and the use of this component in the manufacture of the drug are also disclosed. The compounds help to prevent and / or treat cardiac arrhythmias, such as arrhythmias, ventricular arrhythmias, myocardial fibrosis and fibrillation.