Derivatives of 1 - oxa - 2.8 - Grabarsky, IT's The Wrong Guy spiro 4.5 dec - 2 - substituted Eno, processes for their preparation, their use for Preparation of Drugs and drugs containing these compounds

摘要

1-oxa-2, 8-diaza-helix [4.5] dec-2-eno [4.5] substituted by general formula (1),Racemic, pure stereoisomers, especially enantiomers or enantiomers, or in any proportion, in the form or form of their acids or bases, or in the form of their salts, or in a mixture of their stereoisomers, especially their enantiomers and enantiomers, In particular, the physiologically tolerable salts, especially in the form of hydrochloric acid or solution, especially hydrate, wherein: R1 and R2 represent h, c1-8, c1-8, c3-10 (C1-12 tar) - cyclo-10, arilo (C1-12 tar) - arilo and isocyclohexane, respectively,(C1-12) - isopropene or nh-c (= O) - arilo, wherein at least one R1 and R2 is different from h, or R1 and R2 jointly represent - (cr4r5) m - (cr6r7) n-y - (cr8r9) P - (cr10r11) Q, m, N, P and Q respectively, provided that m + n is 1 and P + Q is 1, O represents - ch2-ch2-c (Arlo) = CH2 -;R3 represents H, SO2R12 or COR13; R4, R5, R6, R7, R8, R9, R10 and R11 independently represent H, C1-10alkyl, C3-8cycloalkyl, (C1-6alkyl) -C3-8cycloalkyl, aryl, (C1-6alkyl ) -aryl, heterocyclyl, (C1-6alkyl) -heterocyclyl or C (= O) R14; Y represents CR15R16, NR17 or O; R12 and R13 independently represent one another C1-10alkyl, C3-10cycloalkyl, (C1-6alkyl) -C3-10cycloalkyl, aryl, (C1-6alkyl) -aryl, heterocyclyl, (C1-6alkyl) -heterocyclyl or NR18R19; R14 represents H, C1-10alkyl, C3-8cycloalkyl, (C1-6alkyl) -C3-8cycloalkyl, aryl, (C1-6alkyl) -aryl, heterocyclyl, (C1-6alkyl) -heterocyclyl or OR20;R15 and R16 independently represent H, C1-10alkyl, C3-8cycloalkyl, (C1-6alkyl) -C3-8cycloalkyl, aryl, (C1-6alkyl) -aryl, heterocyclyl, (C1-6alkyl) -heterocyclyl, or C (= O) R21; R17 represents H, C1-10alkyl, C3-8cycloalkyl, (C1-6alkyl) -C3-8cycloalkyl, aryl, (C1-6alkyl) -aryl, heterocyclyl, (C1-6alkyl) -heterocyclyl or C ( = O) R22; R18 and R19 independently represent each other represents H, C1-10alkyl, C3-8cycloalkyl, (C1-6alkyl) -C3-8cycloalkyl, aryl, (C1-6alkyl) -aryl, heterocyclyl, or (C1-alkyl 6) -heterocyclyl; R20 represents represents H, C1-10 alkyl, C3-8 cycloalkyl, (C1-6 alkyl) -C3-8 cycloalkyl, aryl,(C1-6alkyl) -aryl, heterocyclyl, or (C1-6alkyl) -heterocyclyl; R21 represents represents H, C1-10alkyl, C3-8cycloalkyl, (C1-6alkyl) -C3-8cycloalkyl, aryl, (C1-6alkyl) -aryl, heterocyclyl, (C1-6alkyl) -heterocyclyl or OR23 ; R22 represents represents H, C1-10alkyl, C3-8cycloalkyl, (C1-6alkyl) -C3-8cycloalkyl, aryl, (C1-6alkyl) -aryl, heterocyclyl, (C1-6alkyl) -heterocyclyl or OR24 ; and R23 and R24 independently represent each other represents H, C1-10alkyl, C3-8cycloalkyl, (C1-6alkyl) -C3-8cycloalkyl, aryl, (C1-6alkyl) -aryl, heterocyclyl, or (C1alkyl -6) -heterocyclyl; procedures for its preparation,3. For the production of drugs containing these compounds. These compounds are suitable for pain treatment and ultimately for neurological and chronic pain.