Eurotinona and Derivatives thereof, Process for their preparation, microorganism, Pharmaceutical compositions, Process for its production, and use of these derivatives for the preparation of pharmaceutical compositions, and use of said microorganism

摘要

Odina derivative according to general formula (1),Where R1, R2, R3 and R4 respectively mean,Hydrogen or any other form of bitumen, its stereochemical form in any proportion and its mixture, and its physiologically tolerable salts. Formula compound (1) is an inhibitor of kdr-qunasa. Because of its anti angioplasty effect, it is suitable for the prevention and / or treatment of malignant diseases. The formula compound (1) can be obtained by the microbial fermentation of the European Atomic Energy Community (DSM 13872) or the chemical derivative of the compound produced by the above microbial fermentation. So he also mentioned,A programming of formula compounds (1),A use of formula compound (1) to develop drugs for the treatment of malignant diseases and diseases that can be treated by inhibiting kdr-qunasa, and drug synthesis containing at least one formula compound (1).