An Antibody anti VLA - 1, a composition that includes an isolated Nucleic Acid comprising a sequence encoding Said Antibody, a method to determine the level of VLA - 1 cells in a tissue, the hybridoma Antibody, a computer which produces a representation TR

摘要

Described Antibodies that Bind specifically to the VLA Integrin - 1 and Methods of using these Antibodies to treat immune disorders in an individual. Also included are crystal structures of complexes formed by VLA - 1 Antibodies and their ligands, agonists and antagonists and VLA - 1 identified through the use of the coordinates of these structures.More particularly, it describes a composition that includes this Antibody, an isolated Nucleic Acid consisting of a sequence of encoding Said Antibody, a method to determine the level of VLA - 1 cells in a tissue, the hybridoma producing Said Antibody, a Comput Loves to produce a three-dimensional representation of a Molecule or a molecular Complex.And a method of identification of an inhibitor of the I domain of Integrin inhibitor and so established, and a method for treating an individual with an Immune Disorder mediated by the VLA - 1.