An isolated polynucleotide, a host Cell modified by the polynucleotide, a process for producing a Protein with il-22 activity, a Protein produced by Said process, a composition that includes an Antibody that reacts with the Protein immunologically and Art Methods

摘要

Describes an isolated polinucleu00f3tido comprising a Nucleotide sequence selected from the group consisting of: (a) Nucleotide sequence SEQ ID no: 1; (b) The Nucleotide sequence of SEQ ID no: 1 The nucleotide nucleotide 65 601; (c) The Nucleotide sequence of the sequence 2 Qualifications of full length Protein Clone il-22 deposited under accession Number ATCC 207231; or (d)The Nucleotide sequence encoding the full length Protein encoded by the cDNA insert of Clone il-22 deposited under accession Number ATCC 207231; (e) The Nucleotide sequence of a sequence that encodes a Protein of the mature Clone il-22 deposited under the number of AC 207231 ATCC process; (f) a Nucleotide sequence that encodes a mature Protein encoded by the insertCDNA clone of il-22 deposited under accession Number ATCC 207231; (g) a Nucleotide sequence that encodes a Protein comprising the Amino Acid Sequence SEQ ID no: 2; (H) a Nucleotide sequence that encodes a Protein that contains a fragment of the sequence of aminou00e1c Go to SEQ ID no: 2Eight contiguous amino acids comprising the Fragment of the SEQ ID no: 2; (i) The Nucleotide sequence of a polinucleu00f3tido hybridizing under conditions at least as stringent as 65u00b0C SSC to 4 x 4 x SSC, or a hundred and Eight Degrees with 50% formamide.With any of the polynucleotide specified by (a) - (f) and (j) The Nucleotide sequence of a polynucleotide that Hybrid under conditions at least as stringent as 4 x SSC to 122 degrees Fahrenheit, or 6 x SSC 40oC formamide with 50%, with any of the polynucleotide specified by (a) - ((f) , and has a length of at least 25% of the length of the SEQ ID no: 1.It also describes a modified polinucleu00f3tido Said host Cell, a process for producing a Protein encoded by the polinucleu00f3tido il-22, a Protein produced by Said process and a composition that includes the Protein.It describes an Antibody that reacts with the Protein immunologically and Treatment Methods of a Pathological condition in a subject associated with the activity of il-22.