Process for obtaining n- (2,6-dimethylphenyl) -1-propyl-2-piperidinecarboxamide enantiomers; process for obtaining non-racemic mixtures between the n- (2,6-dimethylphenyl) -1-propyl-2-piperidinecarboxamide enantiomers; a compound comprising non-racemic mixtures of the n- (2,6-dimethylphenyl) -1-propyl-2-piperidinecarboximide enantiomers; pharmaceutical compositions comprising non-racemic mixtures of n- (2,6-dimethylphenyl) -1-propyl-2-piperidinecarboximide enantiomers

摘要

"PROCEDURE FOR OBTAINING N- (2,6-DIMETHYLPHENIL) -1-PROPIL-2-PIPERIDINOCARBOXAMIDE ENANTIMERS; COMPOSITE UNDERSTANDING NON-RACEMIC MIXTURES OF THE N - NUTRAPHYLENE-ENHANCEMENTS - (2,6,6-DIMETHYLPHENYL) - 1 - PROPIL - 2 PIPERIDINOCARBOXAMIDE; -PYPERIDINCARBOXAMIDE ". The present invention describes a method of separating N- (2,6-dimethylphenyl) -1-propyl-2piperidinecarboxamide enantiomers. Another object of the present invention relates to the enantiomeric manipulation of N- (2,6-dimethylphenyl) -1-propyl-2-piperidinecarboxamide enantiomers in order to obtain compounds and pharmaceutical compositions having varying (S) -N- () enantiomeric excesses. 2,6-dimethylphenyl) -1-propyl-2-piperidinecarboxamide, in order to quantify and determine (R) - N- (2,6-dimethylphenyl) -1-propyl-2-piperidinecarboxamide's participation in anesthetic and cardiotoxic effects. These enantiomerically engineered compounds and compositions have been shown to show significant improvement in their anesthetic properties by having a cardiotoxic profile equivalent to the pure enantiomer, (S) - N- (2,6-dimethylphenyl) -1-propyl-2-piperidinecarboxamide.