Methods to inhibit decrease in transdermal drug flow by inhibiting pathway closure

摘要

"METHODS FOR INHIBITING THE REDUCTION IN TRANSDERMAL DRUG FLOW BY INHIBITION OF CLOSING ROADS". This invention relates to a method for inhibiting a decrease in transdermal flux of an agent being transdermally released or sampled over an extended period of time wherein the release or sampling involves the tearing of at least the stratum corneum layer of the skin. to form pathways through which the agent passes. The desired result is obtained by co-releasing or co-sampling the agent with an amount of at least one anti-scarring agent wherein the amount of the anti-scarring agent is effective to inhibit a decrease in transdermal flux of the agent compared to when the release or Sampling of the agent is performed under substantially identical conditions except in the absence of the anti-scarring agent (s).