Crystalline forms of 6 - (4-chlorophenyl) hydroxy- (3-methyl-3h-imidazol-4-yl) methyl -4- (3-ethynyl-phenyl) -1,3-dihydroxybutanedioate salts -methyl-1h-quinolin-2-one and production method

摘要

"Crystalline Forms of 2,3-DIHYDROXIBUTANODIOATE SALTS OF 6 - [(4-CHLOROPHENYL) -HYDROXY- (3-METHYL-3H-IMIDAZOL-4-IL) -METI L] -4- (3-ETHINYL-PHENYL) - 1-METHYL-1H-QUINOLIN-2-ONA AND PRODUCTION METHOD ". The invention relates to crystalline forms of 6 - [(4-chlorophenyl) hydroxy- (3-methyl-3H-imidazol-4-yl) methyl] -4- (3-ethynyl-phenyl) 2,3-dihydroxybutanedioate salts -1-methyl-1H-quinolin-2-one of the formula below: Formula 1 and to pharmaceutical compositions containing the above compound, methods of treating hyperproliferative diseases, such as cancers, in mammals, especially humans, by administering the compound above, and methods of preparing the crystalline forms of the above compound and similar compounds.