Compound, process for preparing and using same, pharmaceutical composition, and methods for treating pain and functional gastrointestinal disorders

摘要

"COMPOUND, PROCESS FOR PREPARING AND USING THEREOF, PHARMACEUTICAL COMPOSITION, AND METHODS FOR THE TREATMENT OF PAIN AND FUNCTIONAL GASTRINTESTINAL DISORDERS". Compounds of the general formula I: R2 is selected from any of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl, triazolyl, thiazolyl and pyridine N-oxide; R2 is independently selected from ethyl and isopropyl; R3 is independently selected from hydrogen and fluorine; R4 is independently selected from -OH, -NH-2 ~ and -NHSO-2-R5; and W is independently selected from hydrogen, -CF -3 and C 1-6 alkyl, or their salts or separate enantiomers and salts thereof; wherein each heteroaromatic ring R 1 1 2 may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C 1 -C 6 alkyl, NO 2, CF 3, alkoxy C 1 -C 6, chlorine, fluorine, bromine and iodine. Substitutions in the heteroaromatic ring R4 may take place at any position in said ring systems; are disclosed and claimed in the present application, as are the separate enantiomers of the compounds and salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the control of pain, anxiety and functional gastrointestinal disorders.