Heterocyclically substituted 2- (d-phenoxy) pyridine derivatives and related compounds as sodium channel blockers for the treatment of neuronal damage and neurodegenerative conditions

摘要

"HYPEROCYCLIC REPLACED 2- (4-PHENoxy) PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS SODIUM CHANNEL LOCKERS FOR NEURONAL DAMAGE TREATMENT AND NEURODEGENERATIVE CONDITIONS". This invention relates to the aryl substituted pyridines of formula (I) or a pharmaceutically acceptable salt, promedicate or solvate thereof, wherein: Ar is selected from the group consisting of Ar ~ 1 ~, Ar ~ 2 ~, Ar ~ 3 ~, and Ar ~ 4 ~, where Ar ~ 1 ~ is R ~ 1 ~ selected from the group consisting of an optionally substituted alkyl, amino, alkylthiol, C (O) R ~ 10 ~, SO ~ 2 ~ R ~ 10 ~ and OC ( O) NH 2 -; R ~ 2 ~ is -Y ~ m ~ - (CH ~ 2 ~) ~ n ~ -Z 'where: Y is O, S or NR ~ 11 ~, where R ~ 11 ~ is hydrogen or alkyl, Z is a ring saturated heterocyclic, optionally substituted on one or more carbon atoms, m is 0 or 1 and n is 0-6; or a pharmaceutically acceptable salt, promedicate or solvate thereof, wherein Ar and R 1 -R 4 are set forth in the description. The invention also relates to the use of the compounds of formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as lateral amyotrophic sclerosis (ALS) and for treatment, prevention or amelioration of both acute or chronic pain, including diabetic neuropathy and anti-tinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics and as antiarrhythmics.