Compound, pharmaceutical composition, methods for treating or preventing physiological disorders associated with tachykinin excess and pain or inflammation, migraine, emesis, post-terpetic neuralgia, depression or anxiety, and use of a compound

摘要

"COMPOSITION, PHARMACEUTICAL COMPOSITION, METHODS FOR TREATMENT OR PREVENTION OF PHYSIOLOGICAL DISORDERS ASSOCIATED WITH AN EXCESS OF TACHKININS AND PAIN OR INFLAMMATION, THRESHEME, NEURALGIA, POST USE, The present invention relates to compounds of Formula (I) wherein R 1, R 2, R 3, R 4, R 5, R 6, R 7, R 8 and R 10 represent a variety of substituents; A represents NR 9 or O; B represents a bond, CH 2 -, NR 9 9 or O, wherein one or both hydrogen atoms of said CH 2 - moiety may be substituted with one or both of R 7 '. and R 8 or alternatively one of the hydrogen atoms of said CH 2 moiety together with a hydrogen atom of an adjacent carbon is substituted with a double bond; provided that when A is O, then B is NR ^ 9 ^; n is zero, 1 or 2; and pharmaceutically acceptable salts thereof. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or post-terpetic neuralgia.