Pharmaceutical Formulation for oral or topical Administration of hydrophobic compounds not Signature Emulsion

摘要

A method to increase the viscosity of a Pharmaceutical Formulation for oral or topical Administration comprising the steps of combining: (a) an effective amount of one or more active ingredients Hydrophobic; b) 5 to 50% of one or more compounds selected from Esters of poliglice Role or fatty acids of formula (1) ch2or CH2O - - Chor ch2chor - [] nch2 CH2O - - Chor ch2or (1), where n is an integerFrom 4 to 13 and R is H or co # 39 where Rand Rand # 39 is a saturated or unsaturated Hydroxy alkyl C8 - 22 and where at least one group R is Hydrogen; (c) 5 to 50% of one or more compounds Selected polyglycerol Esters of fatty acids and / or unsaturated fatty acids of formula (or 2) ch2or CH2O - - Chor ch2chor - [] nch2 CH2O - - Chor ch2or (2), where n is an integer from 0 to 10 and R is H or d cor Where R is a saturated or unsaturated Hydroxy alkyl C8 - 22, and where at least one group while R is Hydrogen; (d) 5 to 50% of one or more selected compounds Macrogol triglyceride glycerol esters,Partial Glycerides or fatty acids or Esters of polyethylene glycol Fatty Acid in which the average number of ethylene oxide reaction in the synthesis of these substances varies from 50 to 150 moles constantly and the proportion between the components (b) and (d) is from 0.1: 1 to 10: 1; where the above percentages are selected from a total of 100%; and where after Dissolution with water 1:1 in volume, the viscosity of the solution increases to at least 5 times compared with the composition without dilution.