Cell expressing chimeric CD4 receptor, destroying HIV-infected cells and pharmaceutical composition containing such cell

摘要

In the present invention, there is disclosed a therapeutic cell which expresses a proteinaceous membrane-bound chimeric receptor, said receptor comprising (a) an extracellular portion which includes a fragment of CD4 that is separated from said therapeutic cell membrane by at least 48 angstroms or by at least 72 angstroms and is capable of specifically recognizing and binding HIV-infected cells but which does not mediate HIV infection and (b) an intracellular portion that is the signal-transducing portion of a T cell receptor protein, a B cell receptor protein, or an Fv receptor protein and that is capable of signaling said cell to destroy a receptor-bound HIV-infected cell. Disclosed is also a pharmaceutical composition in which such cells are comprised.