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Process for the preparation of stable nicorandil preparations
Process for the preparation of stable nicorandil preparations
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机译:制备稳定的尼可地尔制剂的方法
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摘要
A method for producing a stable preparation containing nicorandil, a saturated higher aliphatic acid or a saturated higher alcohol which is solid at ordinary temperatures, and optionally, an organic acid such as fumaric acid, oxalic acid, salicylic acid, tartaric acid or glutaric acid is disclosed. Nicorandil is useful as a curative for various types of angina pectoris. However, it is unstable in humid conditions and under the compressive pressure exerted by punching operations in tablets making and, therefore, the development of a stable nicorandil preparation has been desired.
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