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A process for producing a stable nicorandil-containing pharmaceutical preparation.

机译:一种生产稳定的含尼可地尔的药物制剂的方法。

摘要

SE describes a method for producing a preparation containing nicorandil A higher aliphatic acid SATURATED OR ALCOHOL SUPERIOR saturated it is solid at ambient temperature and optionally an organic acid, AS fumaric acid, oxalic acid, salicylic acid, ACID tartaric acid or glutaric acid. Nicorandil AS HEALING IS SUITABLE FOR VARIOUS TYPES OF ANGINA. HOWEVER it is unstable in wet conditions and under pressure exerted by COMPRESSIVE tableting OPERATIONS IN THE MANUFACTURE OF PILLS AND THEREFORE HAS DESIRED THE DEVELOPMENT OF STABLE nicorandil preparation.
机译:SE描述了一种制备包含尼可地尔的制剂的方法。该高级脂肪酸饱和或饱和,在环境温度下为固体,并且任选地有机酸,富马酸,草酸,水杨酸,酸性酒石酸或戊二酸。尼古拉地尔适合各种类型的心绞痛的治疗。然而,它在潮湿条件下和在压片过程中在压片操作中所施加的压力下是不稳定的,因此需要开发稳定的尼可地尔制剂。

著录项

  • 公开/公告号ES2054623T3

    专利类型

  • 公开/公告日1994-08-16

    原文格式PDF

  • 申请/专利权人 CHUGAI SEIYAKU KABUSHIKI KAISHA;

    申请/专利号ES19870100549T

  • 发明设计人 IIDA YOSHIMITSU;SUMIDA SHUJI;

    申请日1987-01-16

  • 分类号A61K31/455;A61K9/22;A61K47/44;

  • 国家 ES

  • 入库时间 2022-08-22 04:42:54

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