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Disubstituted acetylenes carrying heteroaromatic and heterobicyclic groups having retinoid-like activity
Disubstituted acetylenes carrying heteroaromatic and heterobicyclic groups having retinoid-like activity
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机译:带有具有类维生素A活性的杂芳族和杂双环基团的双取代乙炔
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摘要
Retinoid-like activity is exhibited by compounds of the formula CHEM where X is S, O, or NR' where R' is hydrogen or lower alkyl; R is hydrogen or lower alkyl; A is pyridyl, thienyl, furyl, pyridazinyl, pyrimidinyl or pyrazinyl; n is 0-5; and B is H, -COOH or a pharmaceutically acceptable salt, ester or amide thereof, -CH2OH or an ether or ester derivative, or -CHO or an acetal derivative, or -COR1 or a ketal derivative where R1 is -(CH2)mCH3 where m is 0-4, or a pharmaceutically acceptable salt thereof.
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