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Compositions comprising antineoplastic anthracycline agents encapsulated in micellular phospholipid particles and processes for their preparation
Compositions comprising antineoplastic anthracycline agents encapsulated in micellular phospholipid particles and processes for their preparation
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机译:包含包裹在微细胞磷脂颗粒中的抗肿瘤药蒽环类药物的组合物及其制备方法
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摘要
Anthracycline anti-neoplastic agents are formulated in phospholipid micellular particles. In a preferred embodiment, the particles are in the form of vesicles which comprise an anthracycline agent, preferably daunorubicin, distearyl phosphatidyl choline, distearyl phosphatidyl glycerol and cholesterol, preferably in a molar ratio of about 1:2:0:0 to about 1:4:20:20. The vesicles are suspended in a low ionic solution such as 5% dextrose at pH 7.4.
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