Topical compsn. for treating glaucoma or ocular hypertension - comprises prostaglandin deriv. with omega side chain contg. ring structure

摘要

Ophthalmological compsn. for topical treatment of glaucoma or ocular hypertension comprises an effective amt. of a deriv. of prostaglandin PGA, PGB, PGD, PGE or OGF in which the omega chain is of formula (I) -C-B-C-D-R2 where C = carbon; B = single, double or triple bond; D = chain with 1-10C opt. interrupted by O, N or 5 heteroatoms, the substits. on each C being H, alkyl (pref. 1-5C) carbonyl or OH; R2 = ring structure such as phenyl opt. substd. by 1-5C alkyl, 1-4C alkoxy, CF3, 1-3C acylamino, NO2, halogen or phenyl gp(s); or an aromatic 5-6-membered heterocycle, e.g. thiazole, imidazole, pyrrolidine, thiophene or oxazole, or 3-7C cycloalkyl or cycloalkenyl opt. substd. by 1-5C alkyl gp(s); in an ophthalmologically compatible carrier.