APPLICATION OF BIOLOGICALLY ACTIVE TAT HIV-1, HIS FRAGMENTS OR DERIVATIVAL CENTERS AND AND OR OWNERSHIPS PLAYBRUSH CREATIVE CHURCHES OUTDOORLETS CREATIVE CHURCHES OUTLETS

摘要

This invention relates to a method for prophylactic and / or therapeutic vaccination and / or treatment and / or diagnosis of HIV / AIDS, other infectious diseases, inflammatory and angiogenic diseases and tumors using the biologically active HIV HIV-1 Tat protein, its fragments or derivatives, as a module with one or more of the following: an antigen, an adjuvant, and a targeting delivery system for specific antigen-presenting cells, including dendritic cells, endothelial cells, and macrophages. In particular, it is claimed that Tat can only be used in its biologically active form as an antigen combined with one or more other antigens, for priming or boosting protective immune responses against himself, as well as against other antigens and / or for selective delivery of this antigen (these antigens), as well as active compounds to dendritic cells, endothelial cells and macrophages, due to its ability to target these antigen-presenting cells (APC) and activate them to mature function and enhance Th-1-type immune responses as an adjuvant. Thus, due to these properties and due to the distribution of these cells in the body (during physiological and pathological disorders), biologically active Tat, its fragments or derivatives containing the RGD-area, can be used for prophylactic, therapeutic and / or diagnostic purposes for HIV / AIDS, other infectious diseases, inflammatory and angiogenic diseases and tumors. The international application was published along with an international search report.