vla - 4 mittepeptiidsed dependent cell association with inhibitors of inflammation, which is used for the treatment of autoimmune diseases, and respiratory

摘要

There is disclosed a genus of non-peptidyl compounds, wherein said compounds are VLA-4 inhibitors useful in treating inflammatory, autoimmune, and respiratory diseases, and wherein said compounds comprise a compound of Formula (1.0.0):and pharmaceutically acceptable salts and other prodrug derivatives thereof, wherein: A is (C1-C6) alkyl, cycloalkyl, aryl, heteroaryl or heterocyclyl as defined herein; where said alkyl, cycloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with 0 to 3 R9; or is a member selected from the group consisiting of the following radicals: A1-NHC(=O)NH-A2-, A1-NHC(=O)O-A2-, A1-OC(=O)NH-A2-, A1-NHSO2NH-A2-, A1-NHC(=O)-A2-, A1-C(=O)NH-A2-, A1-NHSO2-A2-, A1SO2NH-A2-, A1-(CH2)rO-A2-, A1-O(CH2)rA2-, A1-(CH2)rA2-, where A1 is aryl and A2 is aryl or pyridyl where said aryl or pyridyl group is substituted with 0 to 3 R9; -B is oxazolinyl or isoxazolinyl which may be optionally substituted with R9; R2 and R3 are each independently selected from the group consisting of hydrogen and (C1-C6) alkyl substituted with 0 to 3 R13; -R4 is hydrogen; or (C1-C6) alkyl optionally substituted with R13; and the remaining variables are defined as set forth in the specification.