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Process for the preparation of 16beta-methyl steroid and novel intermediates and intermediates used in the process
Process for the preparation of 16beta-methyl steroid and novel intermediates and intermediates used in the process
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机译:制备16β-甲基甾族化合物的方法以及新的中间体和用于该方法的中间体
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摘要
Prodn. of 16 beta -methyl-17 alpha -hydroxy- 4,9(11)-pregnadiene-3,20-dione of formula (I) comprises: (a) treating a 17 alpha -hydroxy-17 beta -nitrile with a dehydrating agent to give a 16,17-dehydro-17-nitrile; (b) protecting the oxo gp. if necessary; (c) reacting with an organometallic methylating agent and hydrolysing the resulting imine to give a methyl ketone; (d) treating with an epoxidising agent in a basic medium to give a 16 alpha ,17 alpha -epoxide; (e) protecting the 20-oxo gp.; (f) reacting with an organometallic methylating agent to give a 16 beta -methyl deriv.; and (g) deprotecting the oxo gps. to give (I).
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