ADVANCED ALENDRONATE SODIUM TRIHYDRATE PHARMACEUTICAL COMPOSITIONS AND PREPARATION METHODS THEREOF

摘要

he invention applies to the formulation of tablets comprisinng a therapeutically effectivee amount of Alendronate Sodium Thihydrate (4-amino-1-hydrooxybutylidene-1,1-bisphosphonicc acid, sodium salt trihydrate) as active ingedient, and Spray Dried Maltose or Mannitol in combination with Crospovidonne and Calcium Steaarate, as well as a methode for their manufacturing by a dry granulation process.