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USE OF EPOTHILONE DERIVATIVES FOR PREPARATION OF PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF REFRACTORY TUMORS
USE OF EPOTHILONE DERIVATIVES FOR PREPARATION OF PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF REFRACTORY TUMORS
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机译:乙匹龙衍生物在制备药物组合物中治疗难治性肿瘤的用途
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摘要
A method of treating tumors in a mammal, especially a human that have demonstrated resistance to oncology with taxane oncology agents is disclosed. The method is effective where the tumor has initially been unresponsive to taxane therapy or has developed resistance during the course of treatment. The method comprising the administration of an epothilone derivative selected from those represented by formula I: The subject epothilone derivatives are advantageous in addition to their enhanced potency and effectiveness against tumors that have demonstrated resistance to therapy with taxane oncology agents in that both are efficacious upon oral administration.
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