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IMIDAZOLE DERIVATIVES FOR MODULATIG SODIUM CHANNELS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USE OF IMIDAZOLE DERIVATIVES FOR PRODUCING PHARMACEUTICAL COMPOSITIONS HAVING SODIUM CHANNELS MODULATING EFFECT
IMIDAZOLE DERIVATIVES FOR MODULATIG SODIUM CHANNELS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USE OF IMIDAZOLE DERIVATIVES FOR PRODUCING PHARMACEUTICAL COMPOSITIONS HAVING SODIUM CHANNELS MODULATING EFFECT
The present invention relates to novel imidazole derivatives of general formula (I) which modulate sodium channels and to pharmaceutical compositions containing them. In the general formula (I), R 1 is, to some extent, alkyl or cycloalkylalkyl or optionally substituted aralkyl; R2 is optionally substituted phenyl or optionally substituted biphenyl; R3 is hydrogen or alkyl; The present invention relates to salts, in particular pharmaceutically acceptable salts, of the above compounds. The present invention also relates to pharmaceutical compositions for the modulation of the sodium channel of the compounds of formula I, which are known in part. HE
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机译:本发明涉及调节钠通道的通式(I)的新型咪唑衍生物,并涉及含有它们的药物组合物。在通式(I)中,R 1在某种程度上是烷基或环烷基烷基或任选取代的芳烷基; R 2为任选取代的苯基或任选取代的联苯; R3是氢或烷基;本发明涉及上述化合物的盐,特别是药学上可接受的盐。本发明还涉及部分已知的用于调节式I化合物的钠通道的药物组合物。他
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