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ISOLATED PEPTIDE OF A DERMATOPHAGOIDES PROTEIN ALLERGEN COMPRISING AT LEAST ONE T-CELL EPITOPE OF THE PROTEIN ALLERGEN
ISOLATED PEPTIDE OF A DERMATOPHAGOIDES PROTEIN ALLERGEN COMPRISING AT LEAST ONE T-CELL EPITOPE OF THE PROTEIN ALLERGEN
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机译:至少含有一个蛋白过敏原的T细胞表位的皮肤病蛋白过敏原的分离肽
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摘要
The present invention provides isolated peptides of the major protein allergens of the genus Dermatophagoides. Peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of a protein allergen selected from the allergens Der p I, Der p II, Der f I, or Der f II. The invention also pertains to modified peptides having similar or enhanced therapeutic properties as the corresponding, naturally-occurring allergen or portion thereof, but having reduced side effects. The invention further provides nucleic acid sequences coding for peptides of the invention. Methods of treatment or of diagnosis of sensitivity to house dust mites in an individual and therapeutic compositions comprising one or more peptides of the invention are also provided.
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机译:本发明提供了Dermatophagoides属的主要蛋白质变应原的分离的肽。在本发明范围内的肽包含选自过敏原Der p I,Der p II,Der f I或Der f II的蛋白质过敏原的至少一个T细胞表位,或优选至少两个T细胞表位。本发明还涉及具有与相应的天然发生的变应原或其部分相似或增强的治疗性质但具有减少的副作用的修饰的肽。本发明进一步提供了编码本发明的肽的核酸序列。还提供了治疗或诊断个体中屋尘螨敏感性的方法以及包含一种或多种本发明肽的治疗组合物。
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