INTERMEDIATES FOR PREPARING HIV-PROTEASE INHIBITOR NELFINAVIR, PROCESS FOR THEIR PREPARATION AND METHODS OF PREPARING NELFINAVIR

摘要

A compound of the formula wherein R1 is heteroaryl; or a group of the formula wherein R2 is an alkyl group, a cycloalkyl group, a heterocycloalkyl group, or O-R6, wherein R6 is an alkyl group, an aralkyl group, or an aryl group; or R1 is a group of the formula 252 ו' בניסן התשס" ד - March 28, 2004 wherein each R3 is independently an alkyl group, a cycloalkyl group, a heterocycloalkyl group, an aryl group, or a heteroaryl group; or R1 is a group of the formula wherein R4 and each R5 independently are an alkyl group, a cycloalkyl group, a heterocycloalkyl group, an aryl group, or a heteroaryl group; and X is OH; OR7, wherein R7 is alkyl or aryl; halogen; pseudohalogen; OSO2R8, wherein R8 is alkyl or aryl; heteroaryl bonded through the heteroatom; or N-hydroxyheterocylic bonded through the oxygen, with the proviso that when R1 is CH3C(O)-, X cannot be - OH; or a pharmaceutically acceptable salt or solvate thereof.